Haematological malignancies are types of cancers affecting blood, bone marrow and lymph nodes. Broadly speaking, there are three major types of blood cancers: leukaemia, lymphoma and myeloma. Of these, the most common blood cancer types include non-Hodgkin lymphoma (NHL), chronic lymphocytic leukaemia (CLL), acute myeloid leukaemia (AML) and multiple myeloma (MM). In the US, a newly diagnosed blood cancer patient is reported every three minutes, and new cases of blood cancers account for approximately 10% of all new cancer diagnoses. Also, an estimated 1.3 million people in the US are either living with or are in remission from blood cancer. Scientific and technological advances have led to a significant improvement in five-year relative survival rates for blood cancers, having more than doubled for lymphoma and more than quadrupled for myeloma and leukaemia over the last 50 years.
As you are aware PharmaVentures is a sector focused advisory firm and we are at the forefront of deal-making activity in the pharmaceutical, biotech, medtech and service sector industries such as CROs and CDMOs. Given the current backdrop and challenges facing companies executing live transactions or contemplating entering acquisition or divestment processes, we thought it may be useful to share with you our thoughts on the current deal-making environment and what we see in the ‘trenches’ of ongoing processes for our clients.
M&A in COVID-19 environment and beyond Keep your perspectiveDownload Request
There is strong appetite for cross-border transactions between China and the rest of the world. Improved overall market environment will encourage attractive deal terms and future market potential. Selecting the right partner and effective communication are key for a successful long-term relationship.
Dancing with the Dragon Cross-border Transactions between China and the WorldDownload Request
This is the first in a series of white papers by the experts at PharmaVentures that explores the challenges of valuing drug candidates at various stages of clinical development. This series is based on the experiences we have encountered using valuation in actual negotiations with the various pitfalls that negotiators and valuation practitioners have while negotiating a deal.
How to Interpret and Negotiate Deal Terms for a Life Science Licensing AgreementDownload Request
In the recent years, the level of interest in Gene Therapy from both industry and academia has been unparalleled. CNS disorders in particular have gained a lot of attention with a considerable emphasis on neurological targets; and this is especially visible when analysing several high-profile deals that occurred in 2018. The biggest stand-out deal was struck by Novartis, buying AveXis for $8.7 billion giving the Basel based biopharma company access to what could potentially be the first one-time only treatment for Spinal Muscular Atrophy (SMA). On top of this, AveXis will also give Novartis access to a promising platform technology based around a non-replicating adeno-associated virus (AAV) capsid that allows penetratration of the blood brain barrier.
The Rise of Gene Therapies in Neurological DiseasesDownload Request
Barely a month passes without an announcement of improved survival rates for non-small cell lung cancer (NSCLC) patients. Much of this has been driven by favouring a personalised medicine approach over the historic “one size fits all” chemotherapy paradigm. Drugs which target specific mutations such as EGFR and ALK have been at the forefront and this has been further supplemented with the application of anti-PD-1/PD-L1 agents (as monotherapies or in combination) where Merck’s Keytruda® (Pembrolizumab) has been leading the charge. In fact, ASCO 2018 has solidified Merck’s dominant position in first line settings.